Publication details

Beat-to-beat variability of pulse wave velocity

Authors

SVAČINOVÁ Jana HIDEGOVÁ Simona SIEGLOVÁ Helena KAŠČÁKOVÁ Zuzana FABŠÍK Martin JAKUBÍK Juraj NOVÁK Jan NOVÁKOVÁ Zuzana HRUŠKOVÁ Jana

Year of publication 2019
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Pulse wave velocity (PWV) increase is a marker of decreased arterial compliance (C). C decreases with increased blood pressure (BP), due to endothelial dysfunction and structural changes of the arterial wall. Increased mean PWV is observed in diabetics as well as in hypertonics. Mean PWV was analysed in many studies, but beat-to-beat changes of the PWV were less described. Aim of this pilot study is analysis of PWV beat-to-beat variability in dependence of body position. PWV was measured in II. type diabetics (DM: 7m/8f, age 68±10 years, BP 158/90±19/9 mmHg) and healthy controls (Con: 5m/6f, age 23±2 years, BP 117/76±9/5 mmHg). PWV was recorded by method based on multichannel full body bioimpedance. Protocol consisted of 6 min of supine (sup) and 6 min of head up tilt in 45°(hut). PWV of left forearm (PWVlf) and left calf (PWVlc) were measured. Variability was counted as mean power spectra of PWV in frequency bands LF (0.04 – 0.15 Hz) and HF (0.15 – 0.5 Hz). Results: LF-PWVlf, HF-PWVlf and HF-PWVlc in sup were higher in DM than in Con. During hut LF-PWVlc and HF-PWVlc increased in both groups; LF-PWVlf and HF-PWVlf increased only in Con. During hut of DM, PWVlf was lower than PWVlc. Decreased ability of arterial wall to dampen blood pressure changes probably could lead to higher PWV variability. This could be caused by hypertension and changed arterial stiffness (differences between groups), or by blood redistribution during body position change (differences between sup/hut and lf/cl). This pilot study showed, that PWV variability was changed by health condition, body position and measured artery position. Clear understanding of mechanism influencing PWV variability requires further study.
Related projects: