Publication details

Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers

Authors

ZAVESKY Ludek JANDÁKOVÁ Eva WEINBERGER Vít MINÁŘ Luboš HANZIKOVA Veronika DUSKOVA Daniela ZAVESKA DRABKOVA Lenka HORINEK Ales

Year of publication 2019
Type Article in Periodical
Magazine / Source Cancer Investigation
MU Faculty or unit

Faculty of Medicine

Citation
Web http://dx.doi.org/10.1080/07357907.2019.1663208
Doi http://dx.doi.org/10.1080/07357907.2019.1663208
Keywords Ovarian cancer; ascites; effusion; microRNA; tumor
Description Ovarian cancer is the deadliest gynecologic cancer. The large-scale microRNA (miRNA) expression profiling and individual miRNA validation was performed to find potential novel biomarkers for ovarian cancer. The most consistent overexpression of miRs-200b-3p, 135 b-5p and 182-5p was found in both ascitic fluid and tumors and suggests their potential as oncogenes. miR-451a was consistently underexpressed so may be a tumor suppressor. Results were inconsistent for miR-204-5p, which was overexpressed in ascitic fluid but underexpressed in tumor tissue. miR-203a-3p was generally overexpressed but this failed to be proved in independent sample set in tissue validation.

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