Publication details

Pentraxin 3 in Noninvasively Obtained Cervical Fluid Samples from Pregnancies Complicated by Preterm Prelabor Rupture of Membranes

Authors

JANKŮ Petr KACEROVSKY Marian ZEDNIKOVA Barbora ANDRYS Ctirad KOLACKOVA Martina DRAHOSOVA Marcela PLISKOVA Lenka ZEMLICKOVA Helena GERYCHOVÁ Romana SIMETKA Ondrej MATLAK Petr JACOBSSON Bo MUSILOVA Ivana

Year of publication 2019
Type Article in Periodical
Magazine / Source Fetal Diagnosis and Therapy
MU Faculty or unit

Faculty of Medicine

Citation
Web http://dx.doi.org/10.1159/000499482
Doi http://dx.doi.org/10.1159/000499482
Keywords Inflammation; Microorganism; Pattern recognition receptor; Preterm birth
Description Problem: To determine the changes of pentraxin 3 (PTX3) level in noninvasively obtained cervical fluid samples from women with preterm prelabor rupture of membranes (PPROM) based on the presence of microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation (IAI), and intra-amniotic infection (the presence of both MIAC and IAI). Methods of Study: A total of 160 women with PPROM were included. Cervical fluid samples were obtained using a Dacron polyester swab and amniotic fluid samples were obtained by transabdominal amniocentesis. Cervical fluid PTX3 levels were assessed using enzyme-linked immunosorbent assay. Results: PTX3 was found in all the cervical fluid samples and its levels were higher in women with MIAC, IAI, and intra-amniotic infection than in women without these conditions. When the women were categorized into four subgroups based on the presence of MIAC and/or IAI, women with intra-amniotic infection had higher cervical fluid PTX3 levels than those with sterile IAI (IAI alone), colonization (MIAC alone), or no MIAC or IAI. A cervical fluid PTX3 level of 11 ng/mL was the best value for identifying the presence of intra-amniotic infection in women with PPROM. Conclusions: PTX3 is a constituent of cervical fluid of women with PPROM. Cervical fluid PTX3 level reflects the situation in the intra-amniotic compartments of women with PPROM. Cervical fluid PTX3 is a potential marker for the noninvasive identification of intra-amniotic infection in PPROM.

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