Publication details

Differences in right-to-left vs left-to-right interventricular conduction times in patients indicated to cardiac resynchronization therapy

Authors

POSPÍŠIL David NOVOTNÝ Tomáš JARKOVSKÝ Jiří FARKASOVÁ Barbora KOZÁK Milan KŘIVAN Lubomír VLAŠÍNOVÁ Jitka KALA Petr SEPŠI Milan

Year of publication 2020
Type Article in Periodical
Magazine / Source PLoS One
MU Faculty or unit

Faculty of Medicine

Citation
Web https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0228731&type=printable
Doi http://dx.doi.org/10.1371/journal.pone.0228731
Keywords ELECTRICAL DELAY; HEART-FAILURE
Description Introduction Differences in conduction times from right ventricle to left ventricle and from left ventricle to right ventricle respectively were observed during biventricular devices implantation when changing pacing vector direction. In this article the phenomenon of interventricular conduction time differences is described and assessed in relationship to various clinical and electrophysiological parameters. Methods In 62 consecutive patients (9 females) interventricular conduction times between right and left ventricle in both directions were measured during cardiac resynchronization therapy device implantation procedure. Complex pacing protocol was performed. Results Investigated individuals was divided into 3 subgroups according to type of interventricular conduction pattern and statistically tested with various clinical data. Substantial differences in right-to-left vs left-to-right conduction times (> 5 ms, range 7-72 ms) were observed in 24 (39%) of all patients. They were more common in patients with dilated cardiomyopathy (20 of 38, 53%) compared to 4 (17%) of 24 patients with coronary artery disease (p = 0.011). The phenomenon occurred more often in hypertensive patients (p = 0.012). Other tested factors were nonsignificant. Conclusions There are almost no data on this topic. The occurrence of conduction difference phenomenon is quite common in dilated cardiomyopathy while it is rare in coronary artery disease. We assume the diffuse nature of the disease and the way of remodeling of myocardium play the main role. Knowledge of this phenomenon could be useful in personalized cardiac resynchronization therapy optimization.
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