Publication details

Protinádorová imunoterapie na bázi dendritických buněk v dětské onkologii

Title in English Dendritic vaccine immunotherapy in pediatric oncology


Year of publication 2019
Type Article in Periodical
Magazine / Source Onkologická revue
MU Faculty or unit

Faculty of Medicine

Keywords dendritic vaccine; glioma; neuroblastoma; child
Description Immunotherpies with dendritic cell vaccines are studied for two decades in children with high risk tumors. Majority of subjects are the late stage of disease and heavily pretreated with immunosupresive therapies. Despite this, laboratory signs of response in humoral and cellular immunity and clinical benefit rate and objective responses are observed. The comparison between studies is limited due to different inclusion criteria, diseases and designs of vaccine manufacturing and route of administration. Further research will be focused on depletion of T regulatory lymphocytes by either mentronomic low dose chemotherapy of concomitant treatment with immune check-point inhibitors. High risk subjects early after induction treatment with tumor response to conventional therapies will be included. The first clinical trial experience of treatment with dendritic cell vaccine in children in Czech Republic is discussed.
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