Publication details

Recombinant human C1 esterase inhibitor as short-term prophylaxis in patients with hereditary angioedema

Authors

VALERIEVA Anna STAEVSKA Maria JESENAK Milos HRUBISKOVA Katarina SOBOTKOVA Marta ZACHOVA Radana HAKL Roman ANDREJEVIC Sladjana SUITER Tobias GRIVCHEVA-PANOVSKA Vesna KARADZA-LAPIC Ljerka SOTERES Daniel SHAPIRO Ralph RUMBYRT Jeffrey TACHDJIAN Raffi MEHTA Vinay HSU F. Ida ZANICHELLI Andrea

Year of publication 2020
Type Article in Periodical
Magazine / Source JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
MU Faculty or unit

Faculty of Medicine

Citation
Web http://dx.doi.org/10.1016/j.jaip.2019.08.011
Doi http://dx.doi.org/10.1016/j.jaip.2019.08.011
Keywords C1-INHIBITOR; ATTACKS; DEFICIENCY; EFFICACY
Description Hereditary angioedema (HAE), an inherited deficiency offunctional C1 esterase inhibitor (C1-INH), is characterized byrecurrent episodes of disabling and often painful swelling insubcutaneous and/or submucosal tissues.1HAE attacks aregenerally unpredictable, but triggers for an attack can includehaving a dental or medical procedure (eg, surgery), other trauma,or stress. A preemptive management plan for patients under-going these types of situations may reduce the risk of HAE at-tacks. Recommendations include administration of short-termprophylaxis in patients with HAE before invasive medical pro-cedures, especially those involving the upper airways or digestivetract, with C1-INH concentrate typically the medication ofchoice.

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