Publication details

Investigation of microRNA expression profiles related tomorphological heterogeneity in triple-negative breast cancer

Authors

KOLECKOVA M. KOLAR Z. EHRMANN J. SVOBODA Marek SLABÝ Ondřej BOUCHAL J. BOUCHALOVA K. JANIKOVA M. SROVNAL J. RADOVÁ Lenka

Year of publication 2019
Type Conference abstract
MU Faculty or unit

Central European Institute of Technology

Citation
Description : Triple-negative breast cancers (TNBCs) are morphologically a heterogeneous group of breast carcinomas with no or minimal hormone receptor and HER2 protein expression or gene amplification. Due to its aggressive nature, novel therapeutic targets are urgently required to improve pathological complete response and clinical outcomes. In tumours, microRNAs (miRs) exhibit both oncogenic and tumour-supressor function. The aim of this study was to indentify a possible association between miRs expression profile and intratumoural morphology within different samples of TNBC.
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