Publication details

The Influence of Microscopic Inflammation at Resection Margins on Early Postoperative Endoscopic Recurrence After Ileocaecal Resection for Crohn's Disease

Authors

POREDSKÁ Karolina KUNOVSKÝ Lumír MAREK Filip KALA Zdeněk PROCHÁZKA Vladimír DOLINA Jiří ZBOŘIL Vladimír KOVALČÍKOVÁ Petra PAVLÍK Tomáš JABANDŽIEV Petr PAVLOVSKÝ Zdeněk VLAŽNÝ Jakub MITÁŠ Ladislav

Year of publication 2020
Type Article in Periodical
Magazine / Source Journal of Crohn's and Colitis
MU Faculty or unit

Faculty of Medicine

Citation
Web https://academic.oup.com/ecco-jcc/article/14/3/361/5566479
Doi http://dx.doi.org/10.1093/ecco-jcc/jjz153
Keywords Crohn's disease; ileocaecal resection; early postoperative endoscopic recurrence
Description Background and Aims: The pathogenesis and risk factors for early postoperative endoscopic recurrence of Crohn's disease [CD] remain unclear. Thus, this study aimed to identify whether histological inflammation at the resection margins after an ileocaecal resection influences endoscopic recurrence. Methods: We have prospectively followed up patients with CD who underwent ileocaecal resection at our hospital between January 2012 and January 2018. The specimens were histologically analysed for inflammation at both of the resection margins [ileal and colonic]. We evaluated whether histological results of the resection margins are correlated with endoscopic recurrence of CD based on colonoscopy 6 months after ileocaecal resection. Second, we assessed the influence of known risk factors and preoperative therapy on endoscopic recurrence of CD. Results: A total of 107 patients were included in our study. Six months after ileocaecal resection, 23 patients [21.5%] had an endoscopic recurrence of CD. The histological signs of CD at the resection margins were associated with a higher endoscopic recurrence [56.5% versus 4.8%, p < 0.001]. Disease duration from diagnosis to surgery [p = 0.006] and the length of the resected bowel [p = 0.019] were significantly longer in patients with endoscopic recurrence. Smoking was also proved to be a risk factor for endoscopic recurrence [p = 0.028]. Conclusions: Histological inflammation at the resection margins was significantly associated with a higher risk of early postoperative endoscopic recurrence after an ileocaecal resection for CD.