Publication details

Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis

Authors

SLEZÁKOVÁ Simona BOŘILOVÁ LINHARTOVÁ Petra BARTOVA Jirina PETANOVA Jitka KUKLÍNEK Pavel FASSMANN Antonín IZAKOVIČOVÁ HOLLÁ Lydie

Year of publication 2020
Type Article in Periodical
Magazine / Source Archives of Oral Biology
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.sciencedirect.com/science/article/pii/S0003996919309975?via%3Dihub
Doi http://dx.doi.org/10.1016/j.archoralbio.2019.104628
Keywords Serotonin transporter gene; SLC6A4; Recurrent aphthous stomatitis; Polymorphism
Description Objective: The aim of this study was to investigate five polymorphisms in the SLC6A4 gene in patients with recurrent aphthous stomatitis (RAS) and healthy controls. Design: Totally, 239 subjects were enrolled in this case-control study: 86 patients with RAS and 153 healthy individuals were genotyped for serotonin transporter length polymorphic region (5-HTTLPR) polymorphism, variable number tandem repeat (STin2) and single nucleotide polymorphisms (rs25531, rs3813034, rs1042173) in the SLC6A4 gene by polymerase chain reaction with/without restriction analysis. Results: No significant differences in the allele or genotype frequencies in all studied polymorphisms between RAS patients and healthy controls (P > 0.05) were detected. However, the haplotype analysis detected a higher frequency of LA12 (HTTLPR, rs25531, STin2) haplotype in RAS patients in comparison with healthy controls (P < 0.05, OR = 1.63, 95 % CI = 1.07-2.49). Conclusions: Our study indicates a possible relationship between SLC6A4 and susceptibility to RAS in the Czech population.
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