Publication details

Baseline Chest Computed Tomography as Standard of Care in High-Risk Hematology Patients

Authors

STEMLER Jannik BRUNS Caroline MELLINGHOFF Sibylle C. ALAKEL Nael AKAN Hamdi ANANDA-RAJAH Michelle AUBERGER Jutta BOJKO Peter CHANDRASEKAR Pranatharthi H CHAYAKULKEEREE Methee COZZI Jossé A. DE KORT Elizabeth A. GROLL Andreas H. HEATH Christopher H. HENZE Larissa JIMENEZ Marcos Hernandes KANJ Souha S. KHANNA Nina KOLDENHOFF Michael LEE Dong-Gun MAGER Alina MARCHESI Francesco MARTINO-BUFARULL Rodrigo NUCCI Marcio OKSI Jarmo PAGANO Livio PHILLIPS Bob PRATTES Juergen PYRPASOPOULOU Athina RABITSCH Werner SCHALK Enrico SCHMIDT-HIEBER Martin SIDHARTHAN Neeraj SOLER-PALACÍN Pere STERN Anat WEINBERGEROVÁ Barbora EL-ZAKHEM Aline CORNELY Oliver A. KOEHLER Philipp

Year of publication 2020
Type Article in Periodical
Magazine / Source Journal of Fungi
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151030/pdf/jof-06-00036.pdf
Doi http://dx.doi.org/10.3390/jof6010036
Keywords invasive aspergillosis; chest computed tomography; hematological patient
Attached files
Description Baseline chest computed tomography (BCT) in high-risk hematology patients allows for the early diagnosis of invasive pulmonary aspergillosis (IPA). The distribution of BCT implementation in hematology departments and impact on outcome is unknown. A web-based questionnaire was J. Fungi 2020, 6, 36 3 of 13 designed. International scientific bodies were invited. The estimated numbers of annually treated hematology patients, chest imaging timepoints and techniques, IPA rates, and follow-up imaging were assessed. In total, 142 physicians from 43 countries participated. Median estimated IPA rate was 8% and did not differ between BCT (9%; IQR 5–15%) and non-BCT centers (7%; IQR 5–10%) (p = 0.69). In high-risk hematology patients, baseline CT is becoming a standard-of-care. Chest X-ray, while inferior, is still widely used. Randomized, controlled trials are needed to investigate the impact of BCT on patient outcome.