Publication details

The fifth cranial nerve in headaches

Authors

EDVINSSON J. C. A. VIGANO A. ALEKSEEVA A. ALIEVA E. ARRUDA R. DE LUCA C. D'ETTORE N. FRATTALE I. KURNUKHINA M. MACEROLA N. MALENKOVA E. MAIOROVA M. NOVIKOVA A. ŘEHULKA Pavel RAPACCINI V. ROSHCHINA O. VANDERSCHUEREN G. ZVAUNE L. ANDREOU A. P. HAANES K. A.

Year of publication 2020
Type Article in Periodical
Magazine / Source JOURNAL OF HEADACHE AND PAIN
MU Faculty or unit

Faculty of Medicine

Citation
Web https://thejournalofheadacheandpain.biomedcentral.com/track/pdf/10.1186/s10194-020-01134-1
Doi http://dx.doi.org/10.1186/s10194-020-01134-1
Keywords Fifth cranial nerve; Trigeminal ganglion; Headache; CGRP; Treatments; Migraine pathophysiology
Description The fifth cranial nerve is the common denominator for many headaches and facial pain pathologies currently known. Projecting from the trigeminal ganglion, in a bipolar manner, it connects to the brainstem and supplies various parts of the head and face with sensory innervation. In this review, we describe the neuroanatomical structures and pathways implicated in the sensation of the trigeminal system. Furthermore, we present the current understanding of several primary headaches, painful neuropathies and their pharmacological treatments. We hope that this overview can elucidate the complex field of headache pathologies, and their link to the trigeminal nerve, to a broader field of young scientists.

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