Publication details

Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential

Authors

MARTÍN MOYANO Paula NĚMEC Václav PARUCH Kamil

Year of publication 2020
Type Article in Periodical
Magazine / Source International Journal of Molecular Sciences
MU Faculty or unit

Faculty of Science

Citation
Web https://doi.org/10.3390/ijms21207549
Doi http://dx.doi.org/10.3390/ijms21207549
Keywords CLK; cdc-like kinase; inhibitor; chemical biology; tool compound; chemical probe; T3; SGC-CLK-1; MU1210; SM08502
Description Protein kinases represent a very pharmacologically attractive class of targets; however, some members of the family still remain rather unexplored. The biology and therapeutic potential of cdc-like kinases (CLKs) have been explored mainly over the last decade and the first CLK inhibitor, compound SM08502, entered clinical trials only recently. This review summarizes the biological roles and therapeutic potential of CLKs and their heretofore published small-molecule inhibitors, with a focus on the compounds' potential to be utilized as quality chemical biology probes.
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