Publication details

Characteristics and Outcome of Patients with Acute Myeloid Leukemia and t(8;16)(p11;p13): Results from an International Collaboration

Authors

KAYSE Sabine HILLS Robert K. KRAMER Michael NOVÁKOVÁ Zuzana ESTEY Elihu H. SHAW Carole MAYER Jiří ZAK Pavel SZOTKOWSKI Tomas CETKOVSKY Petr GRIMWADE David PLATZBECKER Uwe KRÄMER Alwin BURNETT Alan K. HO Anthony D. WALTER Roland B. THIEDE Christian EHNINGER Gerhard RÖLLIG Christoph MÜLLER-TIDOW Carsten RUSSELL Nigel H. SCHLENK Richard F. MARK LEVIS 

Year of publication 2018
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description In adult patients (pts) with acute myeloid leukemia (AML), the balanced translocation t(8;16)(p11;p13) is a very rare abnormality resulting in the fusion of MYST3 and CREBBP. Both genes encode proteins with histone acetyltransferase activity and are involved in transcriptional regulation. Previous small series suggested a poor outcome but neither prospective nor larger retrospective cohort studies are available to support these results.

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