Publication details

INCREASED SERUM LEVELS OF UREA AND CREATININE ARE SURROGATE MARKERS FOR DISRUPTION OF RETINAL PHOTORECEPTOR EXTERNAL LIMITING MEMBRANE AND INNER SEGMENT ELLIPSOID ZONE IN TYPE 2 DIABETES MELLITUS

Authors	SAXENA Sandee RUIA Surabh PRASAD Senthamiz JAIN Asth MISHRA Nibh NATU Shankar M MEYER Carsten H GILHOTRA Jagjit S KRUŽLIAK Peter AKDUMAN Levent
Year of publication	2017
Type	Article in Periodical
Magazine / Source	Retina - The Journal of Retinal and Vitreous Diseases
MU Faculty or unit	Faculty of Medicine
Citation
Web	https://www.ingentaconnect.com/content/wk/iae/2017/00000037/00000002/art00024
Keywords	diabetic retinopathy; diabetes mellitus; ellipsoid zone; external limiting membrane; nephropathy; serum creatinine; spectral-domain optical coherence tomography; serum urea
Description	Purpose: To evaluate the role of serum urea and creatinine as surrogate markers for disruption of retinal photoreceptor external limiting membrane (ELM) and inner segment ellipsoid zone (EZ) in Type 2 diabetic retinopathy (DR) using spectral-domain optical coherence tomography, for the first time. Methods: One hundred and seventeen consecutive cases of Type 2 diabetes mellitus (diabetes without retinopathy [No DR; n = 39], nonproliferative diabetic retinopathy [NPDR; n = 39], proliferative diabetic retinopathy [PDR; n = 39]) and 40 healthy control subjects were included. Serum levels of urea and creatinine were assessed using standard protocol. Spectral-domain optical coherence tomography was used to grade the disruption of ELM and EZ as follows: Grade 0, no disruption of ELM and EZ; Grade 1, ELM disrupted, EZ intact; Grade 2, ELM and EZ disrupted. Data were analyzed statistically. Results: Increase in serum levels of urea (F = 22.93) and creatinine (F = 15.82) and increased grades of disruption of ELM and EZ (gamma = 116.3) were observed with increased severity of DR (P < 0.001). Increase in serum levels of urea (F = 10.45) and creatinine (F = 6.89) was observed with increased grades of disruption of ELM and EZ (P = 0.001). Conclusion: Serum levels of urea and creatinine are surrogate markers for disruption of retinal photoreceptor ELM and EZ on spectral-domain optical coherence tomography in DR.