Publication details

TACSTD2 upregulation is an early reaction to lung infection

Authors

LENÁRT Sára LENÁRT Peter KNOPFOVÁ Lucia KOTASOVÁ Hana PELKOVÁ Vendula SEDLÁKOVÁ Veronika VACEK Ondřej POKLUDOVÁ Jana ČAN Vladimír ŠMARDA Jan SOUČEK Karel HAMPL Aleš BENEŠ Petr

Year of publication 2022
Type Article in Periodical
Magazine / Source Nature Scientific Reports
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.nature.com/articles/s41598-022-13637-9
Doi http://dx.doi.org/10.1038/s41598-022-13637-9
Keywords INNATE IMMUNE-RESPONSE; NF-KAPPA-B; EXPRESSION ATLAS; VIRAL-INFECTION; BARRIER; CELLS; GENE; IDENTIFICATION; CANCER; MURINE
Description TACSTD2 encodes a transmembrane glycoprotein Trop2 commonly overexpressed in carcinomas. While the Trop2 protein was discovered already in 1981 and first antibody-drug conjugate targeting Trop2 were recently approved for cancer therapy, the physiological role of Trop2 is still not fully understood. In this article, we show that TACSTD2/Trop2 expression is evolutionarily conserved in lungs of various vertebrates. By analysis of publicly available transcriptomic data we demonstrate that TACSTD2 level consistently increases in lungs infected with miscellaneous, but mainly viral pathogens. Single cell and subpopulation based transcriptomic data revealed that the major source of TACSTD2 transcript are lung epithelial cells and their progenitors and that TACSTD2 is induced directly in lung epithelial cells following infection. Increase in TACSTD2 expression may represent a mechanism to maintain/restore epithelial barrier function and contribute to regeneration process in infected/damaged lungs.
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