Publication details

Antigen Presentation by Common Variable Immunodeficiency (CVID) B Cells and Monocytes is Unimpaired

Authors

THON Vojtěch EGGENBAUER H. WOLF HM. FISCHER MB. LITZMAN J. LOKAJ J.

Year of publication 1997
Type Article in Periodical
Magazine / Source Clin.Exp.Immunol.
MU Faculty or unit

Faculty of Medicine

Citation
Field Immunology
Keywords common variable immunodeficiency; antigen presentation; B cells; monocytes
Description CVID is a primary immunodeficiency syndrome comprising a heterogeneous group of patients with hypogammaglobulinaemia and defective formation of specific antibodies. Previous studies demonstrated defective T cell responsiveness to antigen in a major subgroup of patients. In the present study we investigated the capacity of peripheral blood monocytes and Epstein-Barr virus (EBV)-transformed B cell lines from seven patients with CVID, including two patients expressing an extended MHC haplotype described to be associated with CVID, to present antigen (Tet. Tox.) to CD4(+) antigen-specific T cell lines from healthy controls. The results presented show an unimpaired capacity of peripheral blood monocytes to present antigen in all patients studied. In addition, the present study demonstrates for the first time that CVID B cells function normally as antigen-presenting cells (APC). These findings indicate that expression of a certain MHC phenotype in CVID is not associated with a defect in the presentation of recall antigen by monocytes and B cells. Based on these studies, uptake, processing and re-expression of recall antigen in association with MHC class II molecules on the APC surface are functional and there is no indication far structural abnormalities of the MHC class II molecules expressed by the patients studied that could be essential for their function in antigen binding and presentation.

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