Publication details
2-Hydroxynaphthalene-1-carboxamides possessing antimycobacterial activity
| Authors | |
|---|---|
| Year of publication | 2022 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | The aim of recent work was to synthetize series of N-(phenyl)-2-hydroxynaphthalene-1-carboxamides with multiple substitution on phenyl ring. 30 compounds with halogen, trifluoromethyl, methyl, methoxy and nitro substituted anilide ring were prepared according to well approved microwave-assisted synthetic method. Structure of novel compounds was confirmed by 1H and 13C NMR, HRMS and IR spectroscopy. Primary in vitro screening of the synthesized compounds was performed against Mycobacterium marinum, Mycobacterium kansasii and Mycobacterium smegmatis. Several compounds showed antimycobacterial activity comparable to standards Pyrazinamide and Rifampicine. |