Publication details

Stereotactic Body Radiotherapy (SBRT) of Pancreatic Cancer-A Critical Review and Practical Consideration

Authors

BURKOŇ Petr TRNA Jan SLÁVIK Marek NĚMEČEK Radim KAZDA Tomáš POSPÍŠIL Petr DASTYCH Milan EID Michal NOVOTNY Ivo PROCHÁZKA Tomáš VRZAL Miroslav

Year of publication 2022
Type Article in Periodical
Magazine / Source Biomedicines
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.mdpi.com/2227-9059/10/10/2480
Doi http://dx.doi.org/10.3390/biomedicines10102480
Keywords pancreatic neoplasms; neoadjuvant therapy; stereotactic body radiotherapy; review
Description Pancreatic cancer is the third leading cause of cancer death in the developed world and is predicted to become the second by 2030. A cure may be achieved only with surgical resection of an early diagnosed disease. Surgery for more advanced disease is challenging and can be contraindicated for many reasons. Neoadjuvant therapy may improve the probability of achieving R0 resection. It consists of systemic treatment followed by radiation therapy applied concurrently or sequentially with cytostatics. A novel approach to irradiation, stereotactic body radiotherapy (SBRT), has the potential to improve treatment results. SBRT can deliver higher doses of radiation to the tumor in only a few treatment fractions. It has attracted significant interest for pancreatic cancer patients, as it is completed quickly, requires less time away from full-dose chemotherapy, and is well-tolerated than conventional radiotherapy. In this review, we aim to provide the reader with a basic overview of current evidence for SBRT indications in the treatment of pancreatic tumors. In the second part of the review, we focus on practical information with respect to SBRT treatment plan preparation the performance of such therapy. Finally, we discuss future directions related to the use of magnetic resonance linear accelerators.

You are running an old browser version. We recommend updating your browser to its latest version.

More info