Publication details
Long-term home parenteral nutrition and profile of amino acids in serum and their loss in urine
| Authors | |
|---|---|
| Year of publication | 2023 |
| Type | Article in Periodical |
| Magazine / Source | British Journal of Nutrition |
| MU Faculty or unit | |
| Citation | |
| Web | https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/longterm-home-parenteral-nutrition-and-profile-of-amino-acids-in-serum-and-their-loss-in-urine/F9AE53803D7AA9C4D5C24F1314EE51BF |
| Doi | http://dx.doi.org/10.1017/S0007114522002008 |
| Keywords | Home parenteral nutrition; Essential amino acids; Ion exchange chromatography; Quality of life |
| Description | Amino acids are an essential part of parenteral nutrition. This study aimed to determine the serum profile of amino acids and their loss in urine in patients with long-term home parenteral nutrition (HPN) during 12 h of infusion in comparison with similar parameters in the remaining 12 has well as in healthy participants. We enrolled forty-five patients with long-term HPN for 6-75 (median, 33) months. The indication for HPN was short bowel syndrome secondary to radical resection of the small intestine following complications of Crohn's disease. HPN was administered via two-chamber all-in-one bags prepared in a hospital pharmacy overnight for 12 h each day. The average dose of amino acids, carbohydrates and fats administered was 1.5, 3.4 and 0.68 g/kg per d, respectively, at an infusion rate of 0.11, 0.28 and 0.06 g/kg per h, respectively. The levels of essential amino acids in the serum of the patients were not significantly different from those in healthy individuals; however, of the non-essential amino acids, cystine and glutamine levels were lower and glycine and ornithine levels were higher in the patients (P < 0.05). Excretion of amino acids in the urine during 12 h of infusion at an infusion rate of 0.11 g/kg per h was 301 mg, while it was 104 mg during the remaining 12 h (P < 0.0001). Our patients on long-term HPN had a normal serum profile of essential amino acids. The total urinary excretion of amino acids during 12 h of infusion accounted for only 0.34 % (0-23-0.46) of the administered dose. |