Publication details

Efficacy and safety of higher oral doses of azaperone to achieve sedation in pigs

Authors

SVOBODA Martin BLAHOVA Jana HOSTOVSKY Martin JARKOVSKÝ Jiří NETOLICKY Jakub PREDNY Patrik SIMKOVA Ivana VANHARA Jonas VASEK Jan

Year of publication 2022
Type Article in Periodical
Magazine / Source Veterinarni Medicina
MU Faculty or unit

Faculty of Medicine

Citation
Web http://vetmed.agriculturejournals.cz/artkey/vet-202211-0001_efficacy-and-safety-of-higher-oral-doses-of-azaperone-to-achieve-sedation-in-pigs.php
Doi http://dx.doi.org/10.17221/56/2022-VETMED
Keywords behaviour; biochemical indicators; pharmacodynamics
Description The aim of this study is to evaluate the possibility of achieving more effective and prolonged sedation in pigs by the oral administration of increased doses of azaperone and to evaluate its safety. This was performed through a prospective randomised and double blinded study. A total of 32 weaned piglets were divided into 4 groups (8 in each group). Group A was given 1 ml of saline orally and served as the control group. Group B received azaperone orally at a dose of 4 mg/kg b.w. Group C received azaperone orally at a dose of 8 mg/kg b.w. Group D was given azaperone orally at a dose of 12 mg/kg b.w. The response to the defined stimulus, movement level, degree of salivation, body temperature, respiratory frequency, blood plasma azaperone concentration and biochemical variables were included in the trial. We found that by increasing the dose of the orally administered azaperone, the onset of the sedation is faster, the end of the sedation starts later and the sedation time is longer. However, the use of higher doses of oral azaperone is not suitable for piglets because the doses negatively affect the respiratory rate, body temperature, some biochemical parameters and cause the immobility of the piglets.

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