Publication details

Hepatopatie indukovaná/asociovaná domácí parenterální výživou (PNALD, IFALD, PNAC)

Title in English Hepatopathy induced/associated home parenteral nutrition (PNAlD, IFAlD, PNAC)
Authors

WOHL Petr ŠENKYŘÍK Michal WOHL Pavel BENEŠ Petr GOJDA Jan KOHOUT Pavel MAŇÁK Jan TĚŠÍNSKÝ Pavel NOVÁK František FENCL Filip KUDLA Michal

Year of publication 2022
Type Article in Periodical
Magazine / Source Diabetologie Metabolismus Endokrinologie Výživa
Citation
Keywords home parenteral nutriton, intestinal failure, parenteral nutrition associated liver disease
Description Home parenteral nutrition (HPN) is life saving therapy for patients with chronic intestinal failure caused by different etiology. Parenteral nutrition associated liver disease or intestinal failure associated liver disease (PNALD/IFALD) emcompasses a wide range of disease from steatosis, cholestasis, jaundice to end stage liver disease (ESLD). Diagnosis and monitoring of liver disease requires a complex of clinical, biochemical, radiological and where appropriate histology examination. It is important that other causes of derranged liver function are excluded before HPN. The management of PNALD/IFALD is based on multidisciplinary cooperation of nutritionist, hepatologist, radiologist and surgeron. ESLD with overt liver failure is an indication for small bowel and liver transplatation/multiviceral transplantation. Isolated small bowel transplantion is indicated for mild PNALD/IFALD cases. The purpose of this article is to discuss the current data dealing with IFALD prevention management and therapy.

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