Publication details

Safety and performance of a novel implantable sensor in the inferior vena cava under acute and chronic intravascular volume modulation

Authors

SHERIDAN Stephen William WETTERLING Friedrich TESTANI Jeffrey Moore BORLAUG Barry A A FUDIM Marat DAMMAN Kevin GRAY Alastair GAINES Peter POLOCZEK Martin MADDEN Stephen JAMES Tucker BUXO Teresa GAUL Robert CORCORAN Louise SWEENEY Fiachra BURKHOFF Daniel

Year of publication 2023
Type Article in Periodical
Magazine / Source European Journal of heart Failure
MU Faculty or unit

Faculty of Medicine

Citation
Web https://onlinelibrary.wiley.com/doi/10.1002/ejhf.2822
Doi http://dx.doi.org/10.1002/ejhf.2822
Keywords Heart failure; Inferior vena cava; Right atrial pressure; Models; Animal; Chronic and acute response; Intravascular congestion
Description Aims The management of congestion is one of the key treatment targets in heart failure. Assessing congestion is, however, difficult. The purpose of this study was to investigate the safety and dynamic response of a novel, passive, inferior vena cava (IVC) sensor in a chronic ovine model.Methods and results A total of 20 sheep divided into three groups were studied in acute and chronic in vivo settings. Group I and Group II included 14 sheep in total with 12 sheep receiving the sensor and two sheep receiving a control device (IVC filter). Group III included an additional six animals for studying responses to volume challenges via infusion of blood and saline solutions. Deployment was 100% successful with all devices implanted; performing as expected with no device-related complications and signals were received at all observations. At similar volume states no significant differences in IVC area normalized to absolute area range were measured (55 +/- 17% on day 0 and 62 +/- 12% on day 120, p = 0.51). Chronically, the sensors were completely integrated with a thin, reendothelialized neointima with no loss of sensitivity to infused volume. Normalized IVC area changed significantly from 25 +/- 17% to 43 +/- 11% (p =0.007) with 300 ml infused. In contrast, right atrial pressure required 1200 ml of infused volume prior to a statistically significant change from 3.1 +/- 2.6 mmHg to 7.5 +/- 2.0 mmHg (p = 0.02).Conclusion In conclusion, IVC area can be measured remotely in real-time using a safe, accurate, wireless, and chronic implantable sensor promising to detect congestion with higher sensitivity than filling pressures.

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