Publication details

Favorable prognostic significance of membranous β-catenin expression and negative prognostic significance of cytoplasmic β-catenin expression in pancreatic cancer

Investor logo
Authors

ROSOVA Blanka PROKS Jan FILIPOVA Alzbeta NIKOLOV Dimitar Hadzi CHLOUPKOVÁ Renata RICHTER Igor SZABO Arpad ROZSYPALOVA Aneta MATEJ Radoslav MELICHAR Bohuslav BUCHLER Tomas DVORAK Josef

Year of publication 2023
Type Article in Periodical
Magazine / Source Neoplasma
MU Faculty or unit

Faculty of Medicine

Citation
Web http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=8233&category_id=189&option=com_virtuemart&vmcchk=1&Itemid=1
Doi http://dx.doi.org/10.4149/neo_2023_230721N380
Keywords beta-catenin cytoplasmic; beta-catenin membranous; CD8+tumor infiltrating lymphocytes; pancreatic ductal adenocarcinoma; primary cilia; programmed cell death protein 1
Attached files
Description The aim of this study was to investigate the prognostic significance of membranous beta-catenin and cytoplasmic beta-catenin expression in pancreatic cancer patients (pts). One hundred pts with histologically verified exocrine pancreatic ductal adenocarcinoma were retrospectively studied. The membranous beta-catenin, cytoplasmic beta-catenin, and cell nucleus beta-catenin expression were immunohistochemically evaluated. The expression of membranous beta-catenin was <5% in none of the pts, 5-25% in one patient, 26-50% in 2 pts, 51-75% in 14 pts, and >75% in 81 pts. The expression of cytoplasmic beta-catenin was <5% in 34 pts, 5-25% in 42 pts, 26-50% in 18 pts, 51-75% in 3 pts, and >75% in one patient. The expression of beta-catenin in the cell nucleus was negative in all pts. At the time of the last follow-up, 21 pts were alive and 79 pts had died. Median OS was 1.3 (0.4-2.3) years in pts with membranous beta-catenin expression <= 75% and 1.7 (1.3-2.1) years in pts with membranous beta-catenin expression >75% (p=0.045). Median OS was (1.3-2.0) 1.6 years in pts with cytoplasmic beta-catenin expression <= 25% and 0.9 (0.5-1.2) years in pts with cytoplasmic beta-catenin expression >25% (p=0.040). In the univariate Cox proportional hazard models HR (95% CI) was 0.556 (0.311-0.995) in pts with membranous beta-catenin expression >75% (p=0.048) and 2.200 (1.216-3.980) in pts with cytoplasmic beta-catenin expression >25% (p=0.009). The present results indicate a favorable prognostic significance of membranous beta-catenin expression in pancreatic cancer.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info