Publication details

Mutually potentiating effects of drugs elevating extracellular adenosine and granulocyte colony-stimulating factor on erythropoietic recovery following 5-fluorouracil-induced haematotoxicity in mice

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Authors

WEITEROVÁ L. HOFER M. POSPÍŠIL Milan ZNOJIL Vladimír VÁCHA Jiří VACEK Antonín PIPALOVÁ Iva

Year of publication 2000
Type Article in Periodical
Magazine / Source Drug Development Research
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Description The ability of drugs increasing the level of extracellular adenosine (dipyridamole, AMP) to activate erythropoiesis (BFU-E in the bone marrow, reticulocytes and RBC in the peripheral blood) when given jointly with G-CSF is described. The observed additivity and synergism of G-CSF with elevated extracellular adenosine in terms of erythropoiesis is an interesting finding with potential implications in clinical practice.
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