Publication details

Epibatidine and analogs - New trends in the development of cognitive enhancers and strong analgetics

Authors

PATOČKA Jiří SCHWANHAEUSER WULFF Kräuff MARINI PALOMEQUE María Victoria

Year of publication 2001
Type Article in Periodical
Magazine / Source Vojenské zdravotnické listy
MU Faculty or unit

Faculty of Medicine

Citation
Web http://www.pmfhk.cz/DEPART/ui/VZL/VZL12001/vzl1_12.htm
Field Pharmacology and pharmaceutical chemistry
Keywords epibatidine;analgetics;poison-dart frog; alkaloid; nicotinic acetylcholine agonist;dementia;Alzheimer's disease;pain;toxin
Description Epibatidine, the natural alkaloid isolated from the skin of the Ecuatorian rainforest poison-dart frog. Epipedobates tricolor and some of its synthetically prepared analogs are strong selective agonists of the nicotinic acetylcholine receptors. All of these substances have an analgesic effect and could be used in medical practice. This is very promising for medicine in the fight against pain as well as against dementia, because nicotinic agonists have been found to improve the performance of a variety of memory tasks in rodents and they are probably beneficial in Alzheimer's disease treatment.

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