Publication details
Kinetics of inhibition of horse liver alcohol-dehydrogenase by p-methylbenzyl hydroperoxide
| Authors | |
|---|---|
| Year of publication | 1993 |
| Type | Article in Periodical |
| Magazine / Source | Journal of Enzyme Inhibition |
| MU Faculty or unit | |
| Citation | |
| Keywords | HORSE LIVER ALCOHOL DEHYDROGENASE; P-METHYLBENZYL HYDROPEROXIDE |
| Description | The complex kinetic behaviour of p-methylbenzyl hydroperoxide in its inhibitory action on horse liver alcohol dehydrogenase was examined. The kinetic patterns are markedly different at very low (<10(-8) M) and high (>10(-7) M) hydroperoxide concentrations. In both cases very low inhibition constants (4nM and 14nM, respectively) were found. A possible mechanistic model based on these results is discussed. |