Publication details
Vliv metamfetaminu na aktivitu P-450 na modelu perfundovaných jater u potkanů Wistar albino
| Title in English | Influence of methamphetamine on the activity of P-450 in the perfused liver of Wistar albino rats |
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| Authors | |
| Year of publication | 2001 |
| Type | Article in Proceedings |
| Conference | In Kongres MEFA 2001; Sborník abstrakt |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | methamphetamine; cytochrome P-450; isolated liver; rat; |
| Description | The study was focused on the influence of methamphetamine (MET)on the activities of CYP 2D and 3A in the isolated perfused rat liver. The results showed that MET significantly increased the activity of both CYP isozymes after 10 days of premedication probably by the indirect mechanism, because it did not influence their activity when administered directly into the perfusion solution. |
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