Publication details
Vliv tiagabinu, citalopramu a valproátu na lokomočě pátrací chování myší ve vztahu k jejich potenciální antidepresivní aktivitě
| Title in English | Effects of tiagabine, valproate and citalopram on locomotor/exploratory behaviour in mice |
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| Authors | |
| Year of publication | 2001 |
| Type | Article in Periodical |
| Magazine / Source | Československá fyziologie |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Description | In our previous studies the group-housed mice serving several times as a stimulus for the behaviour of aggressive opponents exhibited much more of anxiogenic-like behaviour in the Acti-track arena. Their locomotion was suppressed and exhibited predominantly in arena circumference in the novel environment unlike in the group of naive mice - without aversive agonistic experience. In the present study the avoidance of enters into the central arena zone, which represents the anxiogenic-like behaviour in the group-housed mice serving several times as a stimulus for the aggressive isolates, was decreased by citalopram and valproate, the clinically used antidepressants. This was recorded after the doses which did not significantly change the same behaviour in mice without aversive agonistic experience. The similar but nonsignificant changes in exploratory locomotor activity were showed after the pretreatment with the low doses of tiagabine (0.15 and 0.3 mg/kg). The higher dose of 3.0 mg/kg however elicited significant sedative influence. Thus, according to our hypothesis given in the ?Introduction? both citalopram and valproate showed behavioural changes predicting potential antidepressant effects, but tiagabine did not. |
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