Publication details

Effects of sigma ligands BD737 and haloperidol on isolated rat hearts

Authors

NOVÁKOVÁ Marie BRAVENÝ Pavel

Year of publication 2001
Type Article in Periodical
Magazine / Source Physiological Research
MU Faculty or unit

Faculty of Informatics

Citation
Field Physiology
Keywords sigma receptor; sigma ligand; cardiac contractility; cardiac arrhythmias
Description Sigma receptors are known to modulate cardiac contractility in isolated cardiomyocytes. The effects of highly specific sigma receptor ligands BD737 and haloperidol were tested in isolated rat hearts. Previously described arrhythmogenic effects of sigma ligands in cardiac myocytes were confirmed in isolated rat hearts perfused according to Langendorff. The putative inotropic effect of the drugs remains controversial.

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