Publication details

Computer modelling of effect of transversal tubules on excitation - contraction coupling in cardiac cells (Basic study)



Year of publication 2001
Type Article in Proceedings
Conference Engineering Mechanics 2001
MU Faculty or unit

Faculty of Medicine

Field Biophysics
Keywords cardiac cell; T-system; quantitative modelling
Description The transverse tubular system (T-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. As suggested in many resent experimental works it could have a significant effect on cardiac cell function induced by the accumulation or the depletion of ions in restricted tubular space. The aim of our work was to design a mathematical model of electrical activity of cardiac cell including a quantitative description of T-system function and to explore the physio-logical significance of T-system in excitation-contraction coupling quantitatively.
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