The Intramolecular Cycloadditon Reaction of N'-Alkyl-N3-[[(2-cyanophenyl)imino](phenyl)methyl]thioureas

• Authors: MOHAMED Walid Fathalla; ČAJAN Michal; MAREK Jaromír; PAZDERA Pavel
• Year of publication: 2001
• Type: Article in Proceedings
• Conference: Sborník príspevkov 53. zjazd Chemických spoločností
• MU Faculty or unit: Faculty of Science
• Field: Organic chemistry
• Keywords: Quinazolines; thioureas; domino-reactions
• Description: The intramolecular cycloaddition reaction of N1-R- or N1,N1-Di-R-N3-[[(2-cyanophenyl)imino](phenyl)-methyl]thioureas formed in situ by addition of amines to N2-(2-cyanophenyl)-N1-thioxo-methylidenebenzene-1-carboximidamide 1 were investigated. These thioureas undergo cyclization folowed by Dimroth rearrangement and quinazolin-4-yl or quinazolin-4-ylidene thioureas were identified.

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