Publication details

NAŠE ZKUŠENOSTI S INTRAARTERIÁLNI LOKOREGIONÁLNI CHEMOTERAPII METASTATICKÉHO KOLOREKTÁLNÍHO KARCINOMU DO JATER

Title in English Our experience with intraarterial locoregional chemotherapy of colorectal carcinoma metastatizing into the liver
Authors

KISS Igor MARKOVÁ J TOMÁŠEK Jiří VYZULA Rostislav VÁLEK Vlastimil BOUDNÝ Jaroslav KALA Zdeněk HANKE Ivo OSTRÍŽEK Tomáš LEYPOLD Jindřich

Year of publication 2001
Type Monograph
MU Faculty or unit

Faculty of Medicine

Citation
Description : Locoregional chemotherapy is one of the possible ways of treatment of inoperable metastatic affection of the liver by colorectal carcinoma. The advantage of regional administration of the cytostatic is the possibility to achieve a higher local concentration of the cytostatic associated with a higher percentage of therapeutic responses. In our department we preferred combined locoregional intraarterial chemotherapy (5-fluorouracil/Mitmycin C/Doxorubicin) combined with systemic intravenous chemotherapy (5-fluorouracil/leukovirin). Locoregional cghemotherapy was administered in the majority as chemotherapy of series 2 or 3 with a very good tolerance. In 2/19 patients we observed marked diminution of liver metastases and subsequent operability and with a duration of complete response for 13 and 18 months. In 7/19 patients a partial therapeutic response was achieved. The total therapeutic response (complete and partial) was 47%. Locoregional chemotherapy attains a higher therapeutic response as compared with systemic chemotherapy and is associated with an acceptable toxicity.

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