Publication details
Vliv felbamátu na explorační chování myší podobný účinkům antidepresiv
| Title in English | ANTIDEPRESSIVE-LIKE FELBAMATE EFFECTS ON EXPLORATORY BEHAVIOUR IN MICE |
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| Authors | |
| Year of publication | 2003 |
| Type | Article in Periodical |
| Magazine / Source | Psychiatrie |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | antidepressant; felbamate; motor behaviour; mouse |
| Description | Felbamate belongs to a class of the 3rd generation antiepileptics which are reported from clinics to show psychotropic, especially antidepressant effects. Recently we have found that felbamate produces tranquillizing effects on aggressivity in the model of agonistic behaviour in singly-housed male mice on paired interactions with group-housed partners. In the present study, the group-housed mice which served several times as opponents to aggressive isolates were investigated for changes in their locomotor/exploratory behaviour in the open field of the Actitrack apparatus (Panlab, S.L., Spain). Such behaviour is suppressed by an aversive experience of aggressive interactions in group-housed partners and antidepressants were found to disinhibit it (Šulcová A.: Psychopharmacology, 2000,Suppl. 1,126) Felbamate was administered orally, 30 min before observations, to two groups of group-housed mice, with and without aversive behavioural experience, at the doses of 15, 60 and 240 mg/kg. Both the two higher doses significantly disinhibited locomotor/exploratory behaviour in mice experienced with aggressive interactions, while producing no marked effects in the naive mice. These results suggest a potential antidepressive felbamate activity. |
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