Publication details

Sporadic hemangioblastoma of the CNS and von Hippel-Lindau diseases-updated results

Authors

SMRČKA Martin NOVOTNÝ Ondřej SMRČKA Vladimír GAILLYOVÁ Renata KŘEPELOVÁ Anna

Year of publication 2002
Type Article in Proceedings
Conference Cancer Detection and Prevention
MU Faculty or unit

Faculty of Medicine

Citation
Field Neurology, neurosurgery, neurosciences
Keywords hemangioblastoma; Hippel-Lindau; VHL
Description To distinguish Von Hippel-Lindau (VHL) disease from a sporadic case of hemangioblastoma seems to be crucial for the management and follow up of these patients. A new diagnostic protocol on the basis of gene analysis have been started in oru institution. Disclosing a VHL case among those with only a solitary hemangioblastoma in the time of presentation requires an active detection for the mutated VHL gene. The occurrence of a renal cell carcinoma is very likely in VHL patients and the mortality of it has exceeded that of hamangioblastoma due to a better surgical results. Close life-long observation is needed to recognize the carcinoma soon and also for some potential for recurrent or de novo growth of hemangioblastoma.
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