Publication details

Dynamics of CYP2D6 activity and clinical response to paroxetine, alprazolam and their combination in patients with depressive disorder

Authors

HADAŠOVÁ Eva ŽOURKOVÁ Alexandra TOMANDL Josef RAVČUKOVÁ Barbora

Year of publication 2003
Type Article in Periodical
Magazine / Source Chemické listy
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords Genetic polymorphism; CYP2D6; paroxetine; alprazolam; psychiatric patients
Description Dynamics of the paroxetine-induced inhibition of CYP2D6 was followed during the paroxetine therapy in patients using phenotyping and genotyping methods. Another aim of the study was to evaluate the level of the enzyme restoration after discontinuation of the paroxetine treatment. The study has shown that even a profound inhibition of CYP2D6 activity in patients without mutation in the CYP2D6 locus had only minor clinical relevance for treatment effectivity and occurence of adverse effects.
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