Publication details

Možné morfologické a patofyziologické podklady vzniku neuropatické bolesti

Investor logo
Title in English Possible morphological and pathophysical basis of neuropathic pain generation


Year of publication 2004
Type Article in Periodical
Magazine / Source Česká a Slovenská neurologie a neurochirurgie
MU Faculty or unit

Faculty of Medicine

Field Neurology, neurosurgery, neurosciences
Keywords morphological and pathophysiological changes; spinal ganglion; spinal cord; pain fixation
Description Neuropathic pain represents a heterogeneous group of states resulting from primary damage or disease of the nervous system. Pathophysiological changes that participate in generation and fixation of this specific type of pain have been mostly hypothetical until recently. Clinical and experimental findings from the recent years bring new insights into this problem. Authors present an overview of morphological and pathophysiological changes on different levels of the nervous system, beginning with the respective sensors of the peripheral nervous system and ending with the cortical level of the central nervous system. These reasons further justify considering neuropathic pain an extensive complex disease affecting the whole nervous system. Important role in this area is played by the sympathetic nervous system together with modulatory and reorganization changes in afferent pathways, resulting in hyperstimulation of pain pathways. Understanding the morphological and pathophysiological changes participating in generation and fixation of neuropathic pain can be instrumental in targeted pharmacological or surgical therapy and can thus improve the patients prospects of higher quality of life.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info