Comparison of the genome of the oral pathogen, Treponema denticola, with other spirochete genomes.

• Authors: SESHADRI R.; MYERS G.S.A.; TETTELIN H.; EISEN J.A.; HEIDELBERG J.F.; DODSON R.J.; DAVIDSEN T.M.; DEBOY R.T.; FOUTS D.E.; HAFT D.H.; SELENGUT J.; REN O.; BRINKAC L.M.; MADUPU R.; KOLONAY J.; DURKIN S.A.; DAUGHERTY S.C.; SHETTY J.; SHVARTSBEYN A.; GEBREGEORGIS E.; GEER K.; TSEGAYE G.; MALEK J.; AYODEJI B.; SHATSMAN S.; MCLEOD M.P.; ŠMAJS David; HOWELL J.K.; PAL S.; AMIN A.; VASHISTH P.; MCNEILL T.Z.; WEINSTOCK G.M.; NORRIS S.J.; FRASER C.M.; PAULSEN I.T.
• Year of publication: 2004
• Type: Article in Periodical
• Magazine / Source: Proc. Nat. Acad. Sci.
• MU Faculty or unit: Faculty of Medicine
• Field: Genetics and molecular biology
• Description: We present the complete 2,843,201-bp genome sequence of Treponema denticola (ATCC 35405) an oral spirochete associated with periodontal disease. Analysis of the T. denticola genome reveals factors mediating coaggregation, cell signaling, stress protection, and other competitive and cooperative measures, consistent with its pathogenic nature and lifestyle within the mixed-species environment of subgingival dental plaque.