Publication details

Comparison of the effects of cannabidiol in two mouse models of depression

Authors

PISTOVČÁKOVÁ Jana ŠULCOVÁ Alexandra LEONARD Brian

Year of publication 2006
Type Article in Proceedings
Conference Collegium Internationale Neuro-Psychopharmacologicum - Book of Abstracts
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords cannabidiol; animal model of depression; olfactory bulbectomy; social defeat; mice
Description Cannabidiol referred as a potential anxiolytic and antidepressant agent was tested in the mouse models of social defeat and the bilateral olfactory bulbectomy for its antidepressant activity. The behavioural data received in both behavioural tests can support more likely cannabidiol potential anxiolytic than antidepressant-like activity. Cannabidiol significantly disinhibited the suppressed phagocytosis of leukocytes in the OB mice, which resembles effects of the antidepressants in this animal models.
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