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Studium biologických efektů benzo[c]phenanthridinových alkaloidů na nádorových a nenádorových buněčných liniích

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Title in English The study of biological effects benzo[c]phenanthridine alkaloids on tumour and normal cell lines


Year of publication 2006
Type Article in Proceedings
Conference Sborník 50.studentské vědecké konference LF MU
MU Faculty or unit

Faculty of Medicine

Field Genetics and molecular biology
Keywords benzo[c]phenanthridine alkaloids
Description Quarternary benzo[c]phenanthridine alkaloids display a wide spectrum of biological effects and they are discussed as a potential cytostatics.We compared effects of major alkaloids sanguinarine and chelerythrine with a minor derivates sanguirubine, chelirubine, sanguilutine, chelilutine and macarpine.Our results showed that IC50 values of tested alkaloids were comparable with IC50 of routinly used cytostatics. Cytotoxicity of individual alkaloids decreased in this order: MA-SL-CHL-SR-CHR-SA-CHE. HeLa and A-2780 were the most sensitive cell lines. All tested alkaloids appeared to be inductors of apoptosis.
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