Publication details
Elastic properties of ribosomal RNA building blocks: Molecular dynamics study
| Authors | |
|---|---|
| Year of publication | 2007 |
| Type | Article in Proceedings |
| Conference | Strukturní biofyzika makromolekul II |
| MU Faculty or unit | |
| Citation | |
| Field | Physical chemistry and theoretical chemistry |
| Keywords | RNA flexibility; Molecular dynamics |
| Description | Explicit solvent Molecular Dynamics was used to describe the intrinsic flexibility of 23S rRNA Kink-turn motifs (e.g. Kt-38, Kt-42, Kt-58) and 23S rRNA Helix 42-44 (i.e. GTPase associated center rRNA with adjacent Kt-42). We demonstrate how rRNA building blocks with contrasting intrinsic flexibilities can form larger architectures with highly specific patterns of preferred low-energy motions and geometries. Additionally, the preferred low-energy motions of different rRNA motifs (e.g. 23S rRNA Kink-turn motifs, 23S rRNA Helix 42-44 (i.e. GTPase associated center rRNA), 23S rRNA Helix 90-92 (i.e. three-way-junction with A-loop), 23S Sarcin-ricin loop, 16S rRNA Helix 44 and 5S rRNA loop E) will be compared and discussed. |