Publication details

A novel form of non-X-linked hyperigm associated with growth and pubertal disturbances and with lymphoma development.

Authors

MOSCHESE Viviana LITZMAN Jiří CALLEA Francesco CHINI Loredana DEVITO Rita CARSETTI Rita DICESARE Silvia GEISSMAN Frederic BROUSSE Nicolle ROSSI Paolo DURANDY Anne

Year of publication 2006
Type Article in Periodical
Magazine / Source J Pediatr
MU Faculty or unit

Faculty of Medicine

Citation
Field Paediatry
Keywords hyper-IgM; immunodeficiency; growth disturbance; lymphoma
Description HyperIgM syndrome is a heterogenous immunodeficiency characterized by impaired class-switch recombination due to different molecular abnormalities. We report on two female patients affected by a novel syndrome associating HIGM, growth and pubertal disturbances, and severe lymphoid hyperplasia with eventual development into lymphomas, suggesting a DNA repair defect.
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