Publication details

Alternative pathways of programmed cell death are activated in cells with defective caspase-dependent apoptosis

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Year of publication 2008
Type Article in Periodical
Magazine / Source Leukemia Research
MU Faculty or unit

Faculty of Science

Field Oncology and hematology
Keywords apoptosis; autophagy; programmed cell death
Description Loss of programmed cell death pathways is one of the features of malignancy that complicate the response of cancer cells to therapy. Activation of alternative death pathways offers a promising approach to enhance efficiency of cancer chemotherapy. We analysed programmed cell death pathways of v-myb-transformed BM2 monobolasts induced by arsenic trioxide, cycloheximide and camptothecin. We show that cell death is not executed by caspases but rather by alternative cell death pathways: camptothecin induces the lysosome-dependent cell death, arsenic trioxide induces autophagy, and most of cycloheximide-treated BM2 cells die by necrosis. The fact that alternative cell death pathways can be switched in cells with defects in activation and/or function of caspases suggests that understanding and targeting of these pathways could improve therapy on cancer cells suffering from defective apoptosis.
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