Publication details

A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system



Year of publication 2008
Type Article in Periodical
Magazine / Source Progress in Biophysics and Molecular Biology
MU Faculty or unit

Faculty of Medicine

Field Biophysics
Keywords guinea pig; cardiac cell; transverse-axial tubular system; quantitative model
Description A model of guinea-pig cardiac ventricular myocyte incorporating a transverse-axial tubular system (TATS) was developed. The model reproduces frequency-dependent changes of action potential shape and can replicate experimental data showing ion diffusion between the tubular lumen and external solution in guinea-pig myocytes.Theoretical analysis and model simulations show that, due to tight electrical coupling, tubular and surface membranes behave as a homogeneous whole during voltage and current clamp. However, during action potentials, restricted diffusion and ionic currents in TATS cause depletion of tubular Ca2+ and accumulation of tubular K+ (up to 19.8% and +3.4%, respectively, of bulk extracellular values, at 6 Hz). These changes, in turn, decrease ion fluxes across the TATS membrane and decrease sarcoplasmic reticulum (SR) Ca2+ load. Thus, the TATS plays a potentially important role in modulating the function of guinea-pig ventricular myocyte in physiological conditions.
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