Publication details

Phenotype determination of CYP2D6 in psychiatric patients - possibilities and implications

Title in English Phenotype determination of CYP2D6 in psychiatric patients - possibilities and implications.
Authors

JUŘICA Jan ŽOURKOVÁ Alexandra FLODROVÁ Eva MCCASKEY HADAŠOVÁ Eva

Year of publication 2008
Type Article in Periodical
Magazine / Source Prague medical report : interdisciplinary biomedical journal of the First Faculty of Medicine, Charles University in Prague.
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords CYP2D6; phenotype; psychiatry
Description Possibilities of CYP2D6 phenotype and genotype determination in psychiatric patients were discussed. Then, the the influence of phenotype of CYP2D6 on clinical response was evaluated (patients with anxiety disorder on paroxetine treatment; n=16). Influence of phenotype on the adverse effects occurence was evaluated as well (including sexual dysfunctions) in the long term paroxetine treatment(patients treated with paroxetine for more than 3 months; n=50).
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