Publication details

Flowcytometrická analýza plazmatických buněk u mnohočetného myelomu

Title in English Flow cytometric analysis of plasma cells in multiple myeloma


Year of publication 2008
Type Article in Periodical
Magazine / Source Klinická onkologie
MU Faculty or unit

Faculty of Medicine

Field Oncology and hematology
Keywords monoclonal gammopathy; multiple myeloma; plasma cells; flow cytometry
Description Immunophenotyping of myeloma cells is used to characterize the malignant plasma cells and to distinguish them from their normal counterparts. Flow cytometry is mostly used for the diagnosis of plasma cell proliferations but a detailed analysis of plasma cell immunophenotype can identify disease markers that are associated with the progression of monoclonal gammopathy of unknown significance to multiple myeloma (MM), the prognosis of MM, the response to treatment, and the presence of minimal residual disease. The aim of the European Myeloma Network (EMN) is to unify and standardize immunophenotyping methods for the analysis of plasma cells in monoclonal gammopathies.
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