Publication details

Animal behavioural models of depression

Authors

ŠULCOVÁ Alexandra PISTOVČÁKOVÁ Jana

Year of publication 2008
Type Article in Periodical
Magazine / Source The International Journal of Neuropsychopharmacology
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords animal; models; depression; antidepressants
Description The original results presented: a) At the doses used none of drugs tested for their potential antidepressant-like effects (e.g. felbamate, tiagabine, sertindole, amisulpride) changed locomotor behaviour of sham-operated rats, however they inhibited locomotor hyperactivity in the open field test in OB rats. b) Compared to control individuals the group-housed mice repeatedly defeated on interaction with aggressive singly-housed male mouse exhibit significantly higher depression of ambulation in the open field test. This was normalized by clinically proven (e.g. citalopram, valproate) as well as potential antidepressants (e.g. felbamate, rimonabant).
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