Publication details

CXXC5 is a novel BMP4-regulated modulator of Wnt-signaling in neural stem cells

Authors

ANDERSSON Therese SÖDERSTEN Erik DUCKWORTH K. Joshua CASCANTE Anna FRITZ Nicolas SACCHETTI Paola ČERVENKA Igor BRYJA Vítězslav HERMANSON Ola

Year of publication 2009
Type Article in Periodical
Magazine / Source Journal of Biological Chemistry
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords Wnt signalling; CXXC5; neural stem cells
Description In a screen designed to identify novel targets of BMP4 signaling in telencephalic neural stem cells, we found that the levels of the previously uncharacterized factor CXXC5 were reproducibly up-regulated after BMP4 stimulation. We demonstrate that CXXC5 can interact with the Wnt-signaling intermediate Dishevelled and attenuate Wnt signalling. We conclude that CXXC5 is a BMP4-induced inhibitor of Wnt signaling in neural progenitors.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info