Publication details

Aktivace autologních transplantátů hematopoetických kmenových buněk interleukinem 2

Title in English Activation of autologous hematopoietic stem cell transplants with interleukin-2
Authors

HÁJEK Roman KOŘÍSTEK Zdeněk VINKLÁRKOVÁ J. JANOVSKÁ E. KLABUSAY Martin DOUBEK M. DVOŘÁKOVÁ D. BOURKOVÁ L. DUŠEK L. ADLER J. MAYER Jiří VORLÍČEK Jiří

Year of publication 2001
Type Article in Periodical
Magazine / Source Časopis lékařů českých
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords interleukin-2; autologous transplantation; stem cell
Description Recent findings of the role of the immunity in eradication of residual tumour tissue after autologous transplantation rejection leading to extensive studies on T-cell mediated specific antitumor effects or nonspecific NL-cell mediated anticancer effects. We have evaluated on the methods of adoptive cell therapy IL-2 activation of autologous graft in the preclinical conditions. In laboratory conditions we have manipulated with autologous grafts form patients suffering with chronic myelocytic leukemia and patients suffering with multiple myeloma.We have proved the possibility to use IL-2 activated autologous graft in the clinical conditions. Based on our preclinical results experimental clinical trials have been initiated in patients suffering from chronic myelocytic leukemia and multiple myeloma.

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