Publication details

Kinetika hematopoesy po vysokodávkované chemoterapii a autologní transplantaci periferních kmenových buněk

Title in English Kinetics of hematopoiesis after high-dose chemotherapy and autologous peripheral stem cell transplantation
Authors

MAYER Jiří KOŘÍSTEK Zdeněk POSPÍŠIL Z. VÁŠOVÁ Ingrid ADAM Zdeněk HÁJEK Roman KREJČÍ Marta KRÁL Z. NAVRÁTIL M. VORLÍČEK Jiří BOURKOVÁ L. MATÝSKOVÁ M. ADLER J. VINKLÁRKOVÁ J. KLABUSAY Martin KOUTNÁ I. HOFFOVÁ V. SCHMITZOVÁ D. JANOVSKÁ E.

Year of publication 1999
Type Article in Periodical
Magazine / Source Časopis lékařů českých
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords Autologous peripheral blood stem cell transplantation
Description Autologous peripheral blood stem cell transplantation (APBSCT) is gradually replacing autologous bone marrow transplantation in many clinical settings. The key question is how to evaluate the quality of grafts. We analyzed the relationship between hematopoietic reconstitution and characteristics of patients and grafts. CONCLUSIONS: We conclude that the content of progenitors in PBSC grafts and time to booth leukocyte and platelet recovery are best estimated by the number of CD34+ cells (not less than 1 x 10(6)/kg) and CFU-GM (not less than 1 x 10(4)/kg). The number of mononuclear cells in an autologous PBSC graft is not suitable and useful for prediction of engraftment rate. There is probably no additional benefit of reinfusion of more than 8-10 x 10(6) CD34+ cells/kg and/or 50 x 10(4) CFU-GM/kg, because hematopoietic recovery is not more rapid.

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