Publication details
Pyrazolopyridines as Cyclin-Dependent Kinase Inhibitors
| Authors | |
|---|---|
| Year of publication | 2004 |
| Type | Patent |
| MU Faculty or unit | |
| Publisher | World Intellectual Property Organization |
| State | United States |
| Patent's number | WO 2004/026872 A1 |
| Description | In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyridine compds. I [R = (un)substiuted-alkyl, -aryl, -heteroaryl, -heteroarylalkyl, etc.; R1 = H, alkyl or aryl; R2 = H, (un)substituted-alkyl, -alkenyl, -alkynyl, -aryl, etc.; R3 = H, halo, CF3, (un)substituted-alkyl, -aryl, etc.; R4 = H, halo, CF3, (un)substituted-alkyl, -cycloalkyl, -aryl, -heteroaryl, etc.] as inhibitors of cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. Thus, e.g., II was prepd. by condensation of 7-amino-5-phenylpyrazolo[1,5-a]pyridine (prepn. given) with 3-formylpyridine. I possessed excellent CDK inhibitory properties as demonstrated by the IC50 value for III of 0.078 .mu.M in inhibition of CDK2. |